| Identification | Back Directory | [Name]
HDH-PHARMA 26173 | [CAS]
871836-51-0 | [Synonyms]
100182
EOS-61542
HDH-PHARMA 26173
4-chloro-1H-pyrazolo[4
4-Chloro-1H-pyrazolo[4,3-...
4-CHLORO-1H-PYRAZOLO[4,3-C]PYRIDINE
1H-Pyrazolo[4,3-c]pyridine,4-chloro-
4-Chloro-1H-pyrazolo[4,3-c]pyridine 98%
4-chloro-1H-pyrazolo[4,3-c]pyridin-6-aMine
4-Chloro-1H-pyrazolo[4,3-c]pyridine (Related Reference) | [EINECS(EC#)]
937-467-3 | [Molecular Formula]
C6H4ClN3 | [MDL Number]
MFCD11870058 | [MOL File]
871836-51-0.mol | [Molecular Weight]
153.572 |
| Chemical Properties | Back Directory | [Boiling point ]
357.5±22.0 °C(Predicted) | [density ]
1.531 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
solid | [pka]
10.46±0.40(Predicted) | [Appearance]
White to light yellow Solid | [InChI]
InChI=1S/C6H4ClN3/c7-6-4-3-9-10-5(4)1-2-8-6/h1-3H,(H,9,10) | [InChIKey]
FUXZQGSDRGDYGX-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC2NN=CC1=2 |
| Hazard Information | Back Directory | [Uses]
4-Chloro-1H-pyrazolo[4,3-c]pyridine is used to prepare gp120-?CD4 inhibitors. | [Synthesis]
General procedure for the synthesis of 4-chloro-1H-pyrazolo[4,3-c]pyridine using 2,4-dichloronicotinaldehyde as starting material: intermediate 1 (1.7 g, 9.7 mmol) was dissolved in dimethoxyethane (12 ml) at room temperature, followed by addition of hydrazine monohydrate (1.2 ml, 38.6 mmol). The reaction mixture was stirred at 75°C overnight. Upon completion of the reaction, the mixture was concentrated to dryness and the resulting crude product was purified by fast chromatography using 20% to 100% ethyl acetate/petroleum ether gradient elution to afford the target product, 4-chloro-1H-pyrazolo[4,3-c]pyridine, as a white solid (0.82 g, 56% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.60 (d, J = 6.9 Hz, 1H), 8.14 (d, J = 6.0 Hz, 1H), 8.32 (s, 1H); mass spectra (ES + APCI)+: m/z 154 [M + H]+. | [References]
[1] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82
[2] Patent: WO2010/106333, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 118
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 1032
[5] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0403 |
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