| Identification | Back Directory | [Name]
AN-0128 | [CAS]
872044-70-7 | [Synonyms]
AN-0128
CRM0005
ONT 000
ONT0001
ONT-0001
CRM 0005
CRM-0005
ZTLSOLUCMQEGEA-UHFFFAOYSA-N | [Molecular Formula]
C20H16BCl2NO3 | [MDL Number]
MFCD18251581 | [MOL File]
872044-70-7.mol | [Molecular Weight]
400.063 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 125 mg/mL (312.45 mM; Need ultrasonic) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases[1][2]. | [in vivo]
AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss[2]. | Animal Model: | Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)[2] | | Dosage: | 1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle | | Administration: | Daily topical daub for 7 days | | Result: | Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively. |
| Animal Model: | Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)[2] | | Dosage: | 5% with Total toothpaste | | Administration: | Applied daily via a cotton-tip applicator. for 7 days | | Result: | Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss. |
| [storage]
4°C, protect from light | [References]
[1] Baker SJ, et al. Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5963-7. DOI:10.1016/j.bmcl.2006.08.130
[2] Luan Q, et al. Inhibition of experimental periodontitis by a topical boron-based antimicrobial. J Dent Res. 2008 Feb;87(2):148-52. DOI:10.1177/154405910808700208 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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