| Identification | Back Directory | [Name]
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(3R)-3-hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)- | [CAS]
873327-59-4 | [Synonyms]
ARC141990
AR-C141990
ARC-141990
AR C141990
ARC 141990
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(3R)-3-hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)- | [Molecular Formula]
C26H28N4O4S | [MOL File]
873327-59-4.mol | [Molecular Weight]
492.59 |
| Hazard Information | Back Directory | [Description]
AR-C141990 is an inhibitor of lactate transporters . | [Uses]
AR-C141990 (Compound 30) is a potent blocker of the monocarboxylate transporter MCT1 with a Ki of 4.8 nM. AR-C141990 (Compound 30) inhibits CYP3A4 and CYP2C9 with IC50 values of 16 μM[1]. | [References]
[1] Guile SD, et al. Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2260-5. DOI:10.1016/j.bmcl.2006.01.024 |
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