| Identification | Back Directory | [Name]
S29434 | [CAS]
874484-20-5 | [Synonyms]
S29434
2-Furancarboxamide, N-[2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl]- | [Molecular Formula]
C21H18N4O3 | [MOL File]
874484-20-5.mol | [Molecular Weight]
374.39 |
| Chemical Properties | Back Directory | [Boiling point ]
695.0±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: 19.29 mg/mL (51.52 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
13.92±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1]. | [in vivo]
S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1]. | Animal Model: | CH3 wild-type mice[1] | | Dosage: | 1 and 15 mg/kg | | Administration: | Intraperitoneal injection; 1 and 15 mg/kg once | | Result: | Positively affected memory by inhibiting QR2. |
| [References]
[1] Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. DOI:10.1124/mol.118.114231 |
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