| Identification | Back Directory | [Name]
[N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro 1H–inden-2-yl]-2-propanesulfonamide] | [CAS]
875927-64-3 | [Synonyms]
UOS12258
[N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro 1H–inden-2-yl]-2-propanesulfonamide] | [Molecular Formula]
C17H19FN2O2S | [MOL File]
875927-64-3.mol | [Molecular Weight]
334.41 |
| Chemical Properties | Back Directory | [Boiling point ]
502.5±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A solid | [pka]
12.08±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine (HY-N0296)‐impaired rats and water maze learning and retention in aged rats[1]. | [storage]
Store at -20°C | [References]
[1] Ward SE, et al. Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br J Pharmacol. 2017 Mar;174(5):370-385. DOI:10.1111/bph.13696 |
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