| Identification | More | [Name]
4-NITRO-3-(TRIFLUOROMETHYL)PHENOL | [CAS]
88-30-2 | [Synonyms]
2-NITRO-5-HYDROXY(TRIFLUOROMETHYL)BENZENE
3-TRIFLUOROMETHYL-4-NITROPHENOL
4-NITRO-3-(TRIFLUOROMETHYL)PHENOL
4-NITRO-A,A,A-TRIFLUORO-M-CRESOL
5-HYDROXY-2-NITROBENZOTRIFLUORIDE
4-nitro-3-(trifluoromethyl)-pheno
4-nitro-3-(trifluoromethyl)phenolsodiumsalt
4-nitro-alpha,alpha,alpha-trifluoro-m-creso
alpha,alpha,alpha-trifluoro-4-nitro-m-creso
alpha,alpha,alpha-Trifluoro-4-nitro-m-cresol
Dowlap F
dowlapf
Lamprecid
m-Cresol, 4-nitro-alpha,alpha,alpha-trifluoro-
m-Cresol, alpha,alpha,alpha-trifluoro-4-nitro-
m-trifluoromethyl-pheno
Phenol, 4-nitro-3-(trifluoromethyl)-
Phenol, m-trifluoromethyl-
TFM
TMF | [EINECS(EC#)]
201-818-2 | [Molecular Formula]
C7H4F3NO3 | [MDL Number]
MFCD00014714 | [Molecular Weight]
207.11 | [MOL File]
88-30-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
76-79 °C(lit.) | [Boiling point ]
135-138 °C0.01 mm Hg(lit.) | [density ]
1.554 | [vapor pressure ]
0Pa@20°C | [Fp ]
135-138°C/0.01mm | [storage temp. ]
-20°C | [solubility ]
Methanol[soluble in] | [form ]
Crystalline Powder | [pka]
6.07(at 25℃) | [color ]
Yellow | [Water Solubility ]
15.05g/L@20°C | [Merck ]
14,9253 | [BRN ]
2053698 | [Henry's Law Constant]
5.2×102 mol/(m3Pa) at 25℃, HSDB (2015) | [InChI]
1S/C7H4F3NO3/c8-7(9,10)5-3-4(12)1-2-6(5)11(13)14/h1-3,12H | [InChIKey]
ZEFMBAFMCSYJOO-UHFFFAOYSA-N | [SMILES]
Oc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O | [LogP]
2.68 at 23℃ | [CAS DataBase Reference]
88-30-2(CAS DataBase Reference) | [EPA Substance Registry System]
3-Trifluoromethyl-4-nitrophenol (88-30-2) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302+H312+H332-H315-H319-H335 | [Precautionary statements ]
P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
2588 | [WGK Germany ]
3
| [RTECS ]
GP3520000
| [Hazard Note ]
Irritant | [REACH Registrations]
Active | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29089990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Hazardous Substances Data]
88-30-2(Hazardous Substances Data) | [Toxicity]
LD50 oral in mammal (species unspecified): 500mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Uses]
4-Nitro-3-(trifluoromethyl)phenol is used in preparation of Bicyclic Heteroaryl substituted compounds as PAR4 inhibitors. | [Uses]
Lamprey killer. | [Production Methods]
The production of 3-trifluoromethyl-4-nitrophenol involves a multi-step synthetic route starting with the preparation of 3-(trifluoromethyl)-4-nitroacetanilide, which is then hydrolysed using a mixture of concentrated sulphuric acid and water to yield 3-(trifluoromethyl)-4-nitroaniline. This intermediate undergoes diazotization, forming a diazonium salt that is subsequently hydrolysed in a boiling mixture of xylene and aqueous copper sulphate solution, converting the diazonium group into a hydroxyl group and producing the final phenol compound. | [Flammability and Explosibility]
Notclassified(100%) | [Mechanism of action]
There are three mainmechanisms (i) disruption of mitochondrial function, (ii) ATP depletion, and (iii) Proton-Motive Force Disruption | [Purification Methods]
Crystallise the nitrophenol from *benzene or from pet ether/*benzene mixture. [Beilstein 6 III 1328.] | [Pesticide Type]
Piscicide, Lampricide |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|