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880549-30-4

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880549-30-4 Structure

880549-30-4 Structure
IdentificationBack Directory
[Name]

AMD 070 hydrochloride
[CAS]

880549-30-4
[Synonyms]

AMD-070 HCl
Mavorixafor HCl
AMD070 hydrochloride
AMD 070 hydrochloride
AMD-070 (hydrochloride)
AMD-070 (HCl 75%(w/w%))
AMD-11070 HYDROCHLORIDE
Mavorixafor (AMD-070) triHCl
AMD-070 hydrochloride(Mavorixafor)
AMD070 HYDROCHLORIDE; AMD 070 HYDROCHLORIDE
N1-(1H-Benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine hydrochloride
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine monohydrochloride
[Molecular Formula]

C21H28ClN5
[MDL Number]

MFCD23160058
[MOL File]

880549-30-4.mol
[Molecular Weight]

385.94
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

white to beige
[InChIKey]

DBNMEMJSDAAGNZ-FYZYNONXSA-N
[SMILES]

NCCCCN([C@@H]1C2=NC=CC=C2CCC1)CC3=NC4=C(C=CC=C4)N3.Cl
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine Monohydrochloride is a potent and selective antagonist of CXCR4. It is also an inhibitor of X4-tropic HIV virus.
[Biological Activity]

AMD070 (AMD11070) is an orally activereversible and selective CXCR4 (CD184fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) th at inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM.
[in vivo]

Mavorixafor (2 mg/kg; po; once a day; for 49 days) hydrochloride significantly inhibits the lung metastasis of B88 SDF 1 cells in nude mice[2].

Animal Model:BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells[2]
Dosage:2 mg/kg
Administration:Oral administration; once a day; for 49 days
Result:A significant reduction in the number of metastatic lung nodules was observed in the mice.
[IC 50]

125I-CXCL12-CXCR4: 13 nM (IC50); HIV-1 (NL4.3 strain): 1 nM (IC50, In MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC50, In PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, In MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, In PBMCs)
Spectrum DetailBack Directory
[Spectrum Detail]

AMD 070 hydrochloride(880549-30-4)1HNMR
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