| Identification | More | [Name]
2,6-Dibromo-4-(trifluoromethoxy)aniline | [CAS]
88149-49-9 | [Synonyms]
2,6-DIBROMO-4-(TRIFLUOROMETHOXY)ANILINE
3,5-DIBROMO-4-AMINOTRIFLUOROMETHOXY BENZENE
3,5-Dibromo-4-(trifluoromethoxy)aniline
3.5-Dibromo-4-Aminotrifluoromethoxybenzen
3,5-Dibromo-4-Aminotrifluoromethoxy
3,5-dibromo-5-AminoTrifluoromethoxybenzene
4-Amino-3,5-dibromotrifluoromethoxybenzene
2,6-Dibromo-4-(trifluoromethoxy)aniline 97%
2,6-Dibromo-4-(trifluoromethoxy)aniline97%
3,5-DIBROMO-4-AMINOTRIFLUOROMETHOXY BENZENE 99+% | [EINECS(EC#)]
201-805-1 | [Molecular Formula]
C7H4Br2F3NO | [MDL Number]
MFCD00153113 | [Molecular Weight]
334.92 | [MOL File]
88149-49-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
70-74 °C(lit.)
| [Boiling point ]
65/0.1mm | [density ]
2.036±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
-0.38±0.10(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C7H4Br2F3NO/c8-4-1-3(14-7(10,11)12)2-5(9)6(4)13/h1-2H,13H2 | [InChIKey]
JBSWOEGXMADXOU-UHFFFAOYSA-N | [SMILES]
C1(N)=C(Br)C=C(OC(F)(F)F)C=C1Br | [CAS DataBase Reference]
88149-49-9(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
2,6-Dibromo-4-(trifluoromethoxy)benzenamine is used in the synthesis of novel pyridylpyrazole acid derivatives in the preparation of agricultural insecticides. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29222990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light pink powder | [Synthesis]
The general procedure for the synthesis of 2,6-dibromo-4-(trifluoromethoxy)aniline from p-trifluoromethoxyaniline was as follows: first, 156 g of the crystallized mother liquor containing sodium sulfate was filtered into a 250 mL four-necked flask and the stirring apparatus was started. Subsequently, 17.5 g (0.175 mol) of the reagent was slowly added dropwise, followed by 36.5 g of sodium bromide (0.354 mol) and 30 g (99% purity, 0.168 mol) of 4-trifluoromethoxyaniline. The temperature of the reaction system was adjusted to above 30 °C and the dropwise addition of 38 g of 35% hydrogen peroxide solution was started. During the dropwise addition, if the temperature increased to 50 °C, the reaction temperature was controlled between 50 and 55 °C by adjusting the dropwise acceleration of the coolant. After the dropwise addition was completed, the reaction temperature was maintained to drop and the reaction was continued to be held for 3 hours. Upon completion of the reaction, the system was cooled to about 30°C and the filtration operation was carried out. The resulting filter cake was dried to obtain 55.8 g of white crystals of 2,6-dibromo-4-trifluoromethoxyaniline, which was analyzed by high performance liquid chromatography (HPLC) with a purity of 99.6% and a yield of 99.2%. | [References]
[1] Patent: CN106631839, 2017, A. Location in patent: Paragraph 0022-0033
[2] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639 |
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