| Identification | Back Directory | [Name]
CCT129957 | [CAS]
883098-58-6 | [Synonyms]
CCT129957
CCT129957,CCT-129957
1H-Indole-2-carboxamide, 7-nitro-N-(2-phenylethyl)- | [Molecular Formula]
C17H15N3O3 | [MDL Number]
MFCD02180414 | [MOL File]
883098-58-6.mol | [Molecular Weight]
309.32 |
| Chemical Properties | Back Directory | [Boiling point ]
632.7±45.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (323.29 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.41±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2]. | [storage]
Store at -20°C | [References]
[1] Reynisson J, et al. The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem. 2009 Apr 15;17(8):3169-76. DOI:10.1016/j.bmc.2009.02.049
[2] Feng L, et al. The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem. 2012 Aug;54:463-9. DOI:10.1016/j.ejmech.2012.05.029 |
|
|