| Identification | Back Directory | [Name]
3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5-dione | [CAS]
883956-47-6 | [Synonyms]
SRI-37240
3-cyclohexyl-10-methyl-2-phenylpyrimido[4,5-b]quinoline-4,5-dione
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 3-cyclohexyl-10-methyl-2-phenyl- | [Molecular Formula]
C24H23N3O2 | [MOL File]
883956-47-6.mol | [Molecular Weight]
385.46 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 11.36 mg/mL (29.47 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1]. | [References]
[1] Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12(1):4358. DOI:10.1038/s41467-021-24575-x |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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