| Identification | Back Directory | [Name]
Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetrasodium salt (9CI) | [CAS]
88453-52-5 | [Synonyms]
Adenosine-5'-O-(3-thiotriphosphate) sodium
Adenosine-5'-O-(3-thiotriphosphate) (sodium salt)
Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetrasodium salt (9CI) | [Molecular Formula]
C10H17N5NaO12P3S | [MOL File]
88453-52-5.mol | [Molecular Weight]
547.24 |
| Hazard Information | Back Directory | [Uses]
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis[1][2][3][4][5]. | [in vivo]
ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3].
ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].
| [References]
[1] Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. DOI:10.1261/rna.2103703
[2] Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. DOI:10.1016/0167-4838(93)90061-u
[3] Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24. DOI:10.1152/ajplung.00283.2007
[4] Ortal Danino, et al. ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460(2):446-50. DOI:10.1016/j.bbrc.2015.03.053
[5] J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29(33):7666-76. DOI:10.1021/bi00485a016 |
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