| Identification | Back Directory | [Name]
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS | [CAS]
1638750-95-4 | [Synonyms]
ADU-S100
(MIW815)
MIW815 disodium salt
ADU-S100 disodium salt
ML RR-S2 CDA Sodium Salt
ML RR-S2 CDA disodium salt
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS | [Molecular Formula]
C20H25N10NaO10P2S2 | [MOL File]
1638750-95-4.mol | [Molecular Weight]
714.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Water: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH) |
| Hazard Information | Back Directory | [Uses]
ML RR-S2 CDA sodium salt is used as a cyclic dinucleotide used in the treatment of cancer. It activates dendritic cells which induces a specific T-cell mediated immune response against cancer cells. | [in vivo]
2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1]. | [storage]
Store at -20°C | [References]
[1] LETICIA CORRALES. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.[J]. Cell reports, 2015, 11 7: 1018-1030. DOI: 10.1016/j.celrep.2015.04.031
[2] GILLES BERGER. STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 28: e2111003119. DOI: 10.1073/pnas.2111003119 |
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