| Identification | Back Directory | [Name]
4-Piperidineacetic acid, 1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-, (2S,4R)- | [CAS]
884600-68-4 | [Synonyms]
GSM-1
GSM1,GSM 1
J2.559.799K
GSM 1 (enzyme modulator)
4-Piperidineacetic acid, 1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]-, (2S,4R)- | [Molecular Formula]
C26H31ClF3NO2 | [MDL Number]
MFCD33548810 | [MOL File]
884600-68-4.mol | [Molecular Weight]
481.98 |
| Hazard Information | Back Directory | [Uses]
GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1)[1][2]. | [References]
[1] Richard M, et al. Beta-amyloid Precursor Protein Mutants Respond to Gamma-Secretase Modulators. J Biol Chem. 2010 Jun 4;285(23):17798-810. DOI:10.1074/jbc.M110.103283
[2] Yu Ohki, et al. Phenylpiperidine-type γ-secretase Modulators Target the Transmembrane Domain 1 of Presenilin 1. EMBO J. 2011 Oct 14;30(23):4815-24. DOI:10.1038/emboj.2011.372 |
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