| Identification | Back Directory | [Name]
PGD2-inhibitor | [CAS]
885066-67-1 | [Synonyms]
MDK66671
PGD2-IN-1
PGD2-inhibitor
PGD2 inhibitor 1
PGD2-IN-1?, >98%
PGD2-inhibitor, >98%
prostaglandin D2(PGD2) inhibitor
Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl- | [Molecular Formula]
C23H23Cl2N3O3 | [MDL Number]
MFCD30721575 | [MOL File]
885066-67-1.mol | [Molecular Weight]
460.35 |
| Chemical Properties | Back Directory | [Boiling point ]
682.1±65.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 25 mg/mL (54.31 mM) | [form ]
Solid | [pka]
4.09±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM. | [Biological Activity]
PGD2-IN-1 is a DP receptor antagonist from patent patent WO 2006044732 A2, compound example 15 (d) with IC50 value of 0.3 nM. | [in vitro]
Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion. | [target]
| [References]
[1] Lim, Sungtaek, et al. 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS. WO2006044732A2.
[2] Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75. DOI:10.1016/j.bmcl.2010.11.071 |
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| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|