| Identification | Back Directory | [Name]
7-(4-FLUOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE | [CAS]
885896-54-8 | [Synonyms]
TOSLAB 870935
7-(4-FLUOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
1H-Purine-2,6-dione, 7-[(4-fluorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-
7-[(4-fluorophenyl)methyl]-8-{[2-(1H-indol-3-yl)eth yl]amino}-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purin e-2,6-dione | [Molecular Formula]
C24H23FN6O2 | [MDL Number]
MFCD07621015 | [MOL File]
885896-54-8.mol | [Molecular Weight]
446.48 |
| Hazard Information | Back Directory | [Uses]
PSB-KK1445 is a potent and selective GPR18 agonist with EC50s of 45.4 nM and 124 nM for human and mouse GPR18, respectively. PSB-KK1445 displays >200-fold selectivity versus both CB receptor subtypes, GPR55, and GPR183[1]. | [References]
[1] Andhika B Mahardhika, et al. Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 27;67(12):9896-9926. DOI:10.1021/acs.jmedchem.3c02423 |
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| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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