| Identification | Back Directory | [Name]
3-Quinolinecarboxamide, 4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-N-(2-methylphenyl)-5-oxo- | [CAS]
886358-51-6 | [Synonyms]
4-(Furan-2-yl)-2-methyl-5-oxo-N-(o-tolyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
3-Quinolinecarboxamide, 4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-N-(2-methylphenyl)-5-oxo- | [Molecular Formula]
C22H22N2O3 | [MOL File]
886358-51-6.mol | [Molecular Weight]
362.42 |
| Chemical Properties | Back Directory | [Boiling point ]
590.4±50.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.91±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
FFA3-Agonist-1 is a selective and moderately potent positive allosteric modular (PAM)-agonist of the FFA3 receptor. | [Uses]
FFA3 agonist 1 is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1]. | [References]
[1] Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595. DOI:10.1021/acs.jmedchem.9b02036
[2] Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10. DOI:10.1124/mol.114.093294 |
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