| Identification | Back Directory | [Name]
INCB 3284 diMesylate | [CAS]
887401-93-6 | [Synonyms]
CS-352
INCB3284
Dimesylate
INCB3284 mesylate
INCB 3284 biMesylate
INCB 3284 diMesylate
INCB 3284 dimesylate, >=98%
N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide,methanesulfonic acid
N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
N-[2-({(3R)-1-[trans-4-Hydroxy-4-(6-Methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl}aMino)-2-oxoethyl]-3-(trifluoroMethyl)benzaMide Methanesulfonate (1:2) | [Molecular Formula]
C26H31F3N4O4 | [MDL Number]
MFCD20926352 | [MOL File]
887401-93-6.mol | [Molecular Weight]
520.544 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:11.0(Max Conc. mg/mL);15.43(Max Conc. mM)
DMSO:57.19(Max Conc. mg/mL);80.24(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);7.02(Max Conc. mM)
Water:71.28(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Powder | [color ]
Colorless to light yellow | [InChIKey]
PNPNUHKICDECDH-SEBNIYPMSA-N |
| Hazard Information | Back Directory | [Uses]
Dimesylate is a potent, selective, and orally bioavailable hCCR2 antagonist. | [Biological Activity]
Primary Target
human CCR2 (hCCR2)''Target IC50: 3.7 nM4.7 nMand 84 nM for different assays. | [in vivo]
INCB 3284 (1 mg/kg/day, ip) reduces liver damage, and decreases microglia activation in AOM-treated mice via inhibition on CCR2. INCB 3284 also significantly reduces the pERK1/2 to tERK1/2 ratio, as well as G-protein signaling pathway activity and proinflammatory cytokine production in cortex lysates from mice administed with azoxymethane[2]. | [IC 50]
MCP-1-hCCR2: 3.7 nM (IC50) | [storage]
Store at -20°C |
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