| Identification | Back Directory | [Name]
LUF 6000 | [CAS]
890087-21-5 | [Synonyms]
LUF 6000
LUF-6000;LUF 6000
N-(3,4-Dichlorophenyl)-2-cyclohexyl-1H-imidazo[4,5-c]quinolin-4-amine
2-Cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo[4,5-c]quinolin-4-amine
3H-Imidazo[4,5-c]quinolin-4-amine, 2-cyclohexyl-N-(3,4-dichlorophenyl)- | [Molecular Formula]
C22H20Cl2N4 | [MDL Number]
MFCD25541739 | [MOL File]
890087-21-5.mol | [Molecular Weight]
411.33 |
| Chemical Properties | Back Directory | [Melting point ]
237-240℃ (methanol water ) | [Boiling point ]
650.5±55.0 °C(Predicted) | [density ]
1.401±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 14.29 mg/mL (34.74 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
12.13±0.40(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect[1][2]. | [in vivo]
LUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice[2]. | [storage]
Store at -20°C | [References]
[1] Du L, et al. Species differences and mechanism of action of A3 adenosine receptor allosteric modulators. Purinergic Signal. 2018;14(1):59-71. DOI:10.1007/s11302-017-9592-1
[2] Cohen S, et al. A? adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action. Mediators Inflamm. 2014;2014:708746. DOI:10.1155/2014/708746 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|