| Identification | Back Directory | [Name]
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- | [CAS]
892415-28-0 | [Synonyms]
F2005-0304
EAAT2 activator 1
3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- | [Molecular Formula]
C16H11ClFN3S | [MOL File]
892415-28-0.mol | [Molecular Weight]
331.8 |
| Chemical Properties | Back Directory | [Boiling point ]
527.6±50.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (75.35 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
0.65±0.19(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1]. | [Biological Activity]
EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1]. | [IC 50]
EAAT2 | [References]
[1]. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777. |
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