| Identification | Back Directory | [Name]
2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol | [CAS]
892686-59-8 | [Synonyms]
BD750
BD750 >=98% (HPLC)
2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
2-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol | [Molecular Formula]
C14H13N3OS | [MOL File]
892686-59-8.mol | [Molecular Weight]
271.34 |
| Chemical Properties | Back Directory | [Boiling point ]
509.4±60.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear (warmed) | [form ]
powder | [pka]
7.38±0.20(Predicted) | [color ]
white to light brown |
| Hazard Information | Back Directory | [Uses]
BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2]. | [in vivo]
BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice[2]. | Animal Model: | Female C57BL/6 mice (10 wks old, 19-21 g)[2]. | | Dosage: | 20 μM. | | Administration: | IV, treated DC on d 7, 11 and 15 post the first PTX injection (dpi 7, 11 and 15). | | Result: | Significantly reduced the frequency of Th1 and Th17 cells and increased the percentage of Tregs compared with mice receiving PBS. |
| [IC 50]
JAK3; STAT5 | [References]
[1] Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43. DOI:10.1111/j.1476-5381.2012.02172.x
[2] Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214. DOI:10.2119/molmed.2016.00110 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|