| Identification | More | [Name]
2-AMINO CYCLOPENTANOL | [CAS]
89381-13-5 | [Synonyms]
2-AMINO CYCLOPENTANOL
Cyclopentanol,2-amino-(6CI,7CI,9CI)
trans-2-Amino-cyclopentanol | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD00100903 | [Molecular Weight]
101.15 | [MOL File]
89381-13-5.mol |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of (1S,2S)-2-aminocyclopentanol from the compound (CAS:672310-36-0): 0.900 g (3.82 mmol) of (S,S)-2-benzyloxycarbonylaminocyclopentanol and 0.36 g of 5% palladium-carbon catalyst were added to the reaction system in a 50 mL autoclave. Under nitrogen protection, 4.5 mL of degassed methanol was added to the reaction system. The reaction mixture was stirred at 50 °C for 3 hours under hydrogen pressure of 2 MPa. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated by rotary evaporator to give 0.59 g of crude product. The product was determined to have an enantiomeric excess (ee) percentage of more than 99%. The 1H-NMR (200 MHz, CDCl3) data of the product were as follows: δ 1.2-1.3 (m, 1H), 1.5 (m, 1H), 1.6-1.7 (m, 2H), 1.9-2.0 (m, 2H), 2.3-2.5 (br, 3H), 3.0 (m, 1H), 3.7 (m, 1H). | [References]
[1] Patent: EP1398310, 2004, A1. Location in patent: Page 16-17 |
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