| Identification | Back Directory | [Name]
LDN-212320 | [CAS]
894002-50-7 | [Synonyms]
LDN-212320
LDN-0212320
OSU-0212320
LDN/OSU-0212320
LDN/OSU-0212320;LDN-0212320;OSU-0212320
3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
(3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Pyridazine, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)- | [Molecular Formula]
C17H15N3S | [MDL Number]
MFCD05960679 | [MOL File]
894002-50-7.mol | [Molecular Weight]
293.39 |
| Hazard Information | Back Directory | [Uses]
LDN 212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases. | [in vivo]
LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC[1].
| Animal Model: | Mice[1]. | | Dosage: | 10 or 20 mg/kg. | | Administration: | IP 24 h before the injection of formalin. | | Result: | Significantly attenuated licking and biting behavior during both phases 1 and 2 in a dose-dependent manner compared to formalin-injected mice.
Significantly (P < 0.01 or P < 0.001) reduced the licking and biting behavior.
Significantly increased preference for the displaced object (F3, 13 = 28.03, P < 0.01) compared to formalin-injected mice.
Significantly (P < 0.001) increased interaction time with the displaced object compared to formalin-injected mice.
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| [IC 50]
EAAT2 | [storage]
Store at -20°C |
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Lynnchem
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