| Identification | Back Directory | [Name]
4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE | [CAS]
89466-55-7 | [Synonyms]
4-Chloro-6-methoxy-2-(methylsulfonyl)
4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE
4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine
4-Chloro-2-(methylsulfonyl)-6-methoxypyrimidine
Pyrimidine, 4-chloro-6-methoxy-2-(methylsulfonyl)-
4-Chloro-6-methoxy-2-(methylsulfonyl)pyrimidine ,97%
4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C6H7ClN2O3S | [MDL Number]
MFCD10574963 | [MOL File]
89466-55-7.mol | [Molecular Weight]
222.65 |
| Chemical Properties | Back Directory | [Melting point ]
90-91℃ | [Boiling point ]
405.1±48.0 °C(Predicted) | [density ]
1.449 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-6.47±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
General method: 6-methoxy-2-methylthio-4-chloropyrimidine (5 mmol), tetrabutylammonium bromide (0.16 g, 0.5 mmol, 10 mol%) were mixed with acetone (20 mL) at room temperature and stirred. An aqueous solution of Oxone (12.5 mmol, 2.5 eq.) was slowly added (20 mL) with vigorous stirring. After 4-6 hours of reaction, complete consumption of the feedstock was confirmed by TLC monitoring. The reaction mixture was filtered through a Brewer's funnel and the resulting solid product was washed with water and dried to give 4-chloro-6-methoxy-2-methylsulfonylpyrimidine. The yield, melting point and spectral data of the product are shown below. | [References]
[1] Synthetic Communications, 2018, vol. 48, # 6, p. 714 - 720
[2] Patent: US5599770, 1997, A
[3] Patent: US5723412, 1998, A |
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