| Identification | Back Directory | [Name]
AT 9283, (HCl salt) | [CAS]
896466-61-8 | [Synonyms]
AT-9283 HCl
AT 9283, (HCl salt)
AT9283 hydrochloride
NHFNYIVVGIXBPD-UHFFFAOYSA-N | [Molecular Formula]
C19H24ClN7O2 | [MOL File]
896466-61-8.mol | [Molecular Weight]
417.9 |
| Hazard Information | Back Directory | [Uses]
AT9283 hydrochloride is a multi-targeted kinase inhibitor with anti-tumor activity. AT9283 hydrochloride has been found to effectively inhibit Aurora A and Aurora B kinases, thereby affecting cell proliferation and survival. AT9283 hydrochloride can also inhibit several other kinases, including JAK2 and Abl (T315I)[1]. | [References]
[1] Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity DOI:10.1021/jm800984v |
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