| Identification | Back Directory | [Name]
AZ 876 | [CAS]
898800-26-5 | [Synonyms]
AZ 876
AZ 12260493
AZ-12260493.
AZ-876, AZ12260493
AZ876;AZ-876;AZ 876
AZ876; AZ 876; AZ-876, AZ12260493; AZ 12260493; AZ-12260493.
2-tert-butyl-1,1-dioxo-5-phenyl-4-(4-piperidin-1-ylanilino)-1,2-thiazol-3-one
2-(1,1-Dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone 1,1-dioxide
3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide | [Molecular Formula]
C24H29N3O3S | [MDL Number]
MFCD30377191 | [MOL File]
898800-26-5.mol | [Molecular Weight]
439.57 |
| Chemical Properties | Back Directory | [Boiling point ]
605.3±65.0 °C(Predicted) | [density ]
1.293±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
dmso:94.0(Max Conc. mg/mL);213.84(Max Conc. mM) | [form ]
A solid | [pka]
5.80±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively[1][2]. | [storage]
Store at -20°C | [References]
[1] Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17(3):273-82. DOI:10.1002/ejhf.243
[2] van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63. DOI:10.1111/j.1476-5381.2010.01168.x |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|