| Identification | Back Directory | [Name]
ACONITASE | [CAS]
9024-25-3 | [Synonyms]
ACO1
ACONITASE
EC 4.2.1.3
ACONITATE HYDRATASE
citrate hydro-lyase
Native Porcine Aconitase
ACONITASE, FROM PIG HEART
Ferritin repressor protein
Human ACO1 Protein, His Tag
aconitase from porcine heart
CITRATE [ISOCITRATE] HYDROLYASE
Aconitase, Citrate (isocitrate) hydro-lyase
Anti-IREB1, N-Terminal antibody produced in rabbit
Anti-IREB1, C-Terminal antibody produced in rabbit
Aconitate hydratase, Citrate (isocitrate) hydrolyase
Aconitate hydratase (from Porcine heart), 50% glycerol solution | [MDL Number]
MFCD00130335 |
| Safety Data | Back Directory | [Safety Statements ]
22-24/25 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Toxicity]
Aconitase is the enzyme that reversibly interconverts
citric acid, cis-aconitic acid, and isocitric acid in the
tricarboxylic acid cycle (TCA) (formerly known as the citric
acid or Krebs cycle) by dehydration and hydration reactions.
Aconitase is the target for fluoroacetate, a potent rodenticide,
that condenses with oxaloacetate to yield an aconitase inhibitor
(fluorocitric acid), with resultant accumulation of citric acid
and thus blockage of the TCA cycle, leading to an inhibition
of aerobic energy production. |
| Hazard Information | Back Directory | [Uses]
Aconitase may be usefull in diabetes research as well as to study structural conservation between iron-responsive element binding proteins (IRE-BP) and isomerases . | [Biochem/physiol Actions]
Aconitase catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle. Aconitase is inhibited by cyanide, sulfide and copper and mercury at low concentrations. It is competitively inhibited by trans-aconitate. Aconitase contains an internal Fe-S cluster which is responsible for its activity. |
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Sigma-Aldrich
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Merck KGaA
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Creative Enzymes
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