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90430-59-4

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90430-59-4 Structure

90430-59-4 Structure
IdentificationBack Directory
[Name]

Hydroxy-PEG3-methylamine
[CAS]

90430-59-4
[Synonyms]

MeNH-PEG4-OH
Hydroxy-PEG4-methylamine
Hydroxy-PEG3-methylamine
Methylamino-PEG4-alcohol
5,8,11-Trioxa-2-azatridecan-13-ol
[Molecular Formula]

C9H21NO4
[MDL Number]

MFCD29042347
[MOL File]

90430-59-4.mol
[Molecular Weight]

207.27
Chemical PropertiesBack Directory
[solubility ]

Soluble in Water, DMSO, DCM, DMF
[form ]

Liquid
[color ]

Light yellow to orange
Hazard InformationBack Directory
[Description]

Hydroxy-PEG3-methylamine is a PEG linker containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc.
[Uses]

Hydroxy-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

Hydroxy-PEG3-methylamine(90430-59-4)1HNMR
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