| Identification | Back Directory | [Name]
H-VAL-PRO-LEU-OH | [CAS]
90614-49-6 | [Synonyms]
DIPROTIN B
VAL-PRO-LEU
Val-Pro-Leu-OH
H-VAL-PRO-LEU-OH
L-Val-L-Pro-L-Leu-OH
(-)-L-Val-L-Pro-L-Leu-OH
L-VALYL-L-PROLYL LEUCINE
n-(1-l-valyl-l-prolyl)-l-leucin
2-[[1-(2-amino-3-methylbutanoyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid | [Molecular Formula]
C16H29N3O4 | [MDL Number]
MFCD00057893 | [MOL File]
90614-49-6.mol | [Molecular Weight]
327.42 |
| Chemical Properties | Back Directory | [Boiling point ]
575.9±50.0 °C(Predicted) | [density ]
1.157±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [form ]
White lyophilized powder. | [pka]
3.71±0.21(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2]. | [Definition]
ChEBI: Val-Pro-Leu is an oligopeptide. | [References]
[1] Rahfeld J, et al. Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? Biochim Biophys Acta. 1991 Jan 29;1076(2):314-6. DOI:10.1016/0167-4838(91)90284-7
[2] Hatanaka T, et al. Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity. J Enzyme Inhib Med Chem. 2014 Dec;29(6):823-8. DOI:10.3109/14756366.2013.858143 |
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