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906147-24-8

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906147-24-8 Structure

906147-24-8 Structure
IdentificationBack Directory
[Name]

1H-Indole-3-acetamide, N-[1,1'-biphenyl]-2-yl-α-oxo-
[CAS]

906147-24-8
[Synonyms]

PTK7/β-catenin-IN-1
1H-Indole-3-acetamide, N-[1,1'-biphenyl]-2-yl-α-oxo-
[Molecular Formula]

C22H16N2O2
[MOL File]

906147-24-8.mol
[Molecular Weight]

340.37
Chemical PropertiesBack Directory
[density ]

1.310±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

11.25±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].
[References]

[1] Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072. DOI:10.1021/acschembio.1c00826
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