| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- | [CAS]
906556-51-2 | [Synonyms]
VUF11211
VUF-11211
VUF 11211
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- | [Molecular Formula]
C26H35Cl2N5O | [MOL File]
906556-51-2.mol | [Molecular Weight]
504.49 |
| Hazard Information | Back Directory | [Description]
VUF11211 is a potent CXCR3 antagonist. It acts by extending from the minor pocket into the major pocket of the transmembrane domains and binding between residues in helices 1 (Y1.39), 2 (W2.60), 3 (F3.32), 4 (D4.60), 6 (Y6.51), and 7 (S7.39, Y7.43). | [Uses]
VUF11211 is an allosteric inverse CXCR3 agonist with a Kd of 0.65 nM[1]. | [References]
[1] Scholten DJ, et al. Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3. Mol Pharmacol. 2015 Apr;87(4):639-48. DOI:10.1124/mol.114.095265 |
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