| Identification | More | [Name]
3-N-Boc-amino-azetidine | [CAS]
91188-13-5 | [Synonyms]
3-AMINOAZETIDINE, 3-BOC PROTECTED
3-BOC-AMINOAZETIDINE
3-N-BOC-AMINO-AZETIDINE
AZETIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
TERT-BUTYL AZETIDIN-3-YLCARBAMATE
Carbamic acid, 3-azetidinyl-, 1,1-dimethylethyl ester (9CI)
3-Aminoazetidine, 3-BOC protected 97%
3-BOC-AMINOAZETIDINE 98%
Azetidin-3-yl-carbamic acid tert-butyl ester HCl
azetidine-3-yl-carbamic acid tert-butyl ester
1,1-Dimethylethyl 3-azetidinylcarbamate
3-Boc-Aaminoazetidine | [EINECS(EC#)]
676-108-2 | [Molecular Formula]
C8H16N2O2 | [MDL Number]
MFCD01861759 | [Molecular Weight]
172.22 | [MOL File]
91188-13-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
63-72°C | [Boiling point ]
268℃ | [density ]
1.06 | [Fp ]
116°(241°F) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder | [pka]
12.26±0.40(Predicted) | [color ]
White | [Water Solubility ]
Soluble in water. (5g/100ml) | [InChI]
InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-6-4-9-5-6/h6,9H,4-5H2,1-3H3,(H,10,11) | [InChIKey]
NEMXVXVJGXZDRR-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NC1CNC1 | [CAS DataBase Reference]
91188-13-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
tert-Butyl N-Azetidin-3-ylcarbamate is a versatile reactant used in the preparation of substituted benzothiazoles via copper-catalyzed three-component domino condensation/S-arylation/heterocyclization reactions. Also used in the synthesis and pharmacokinetic evaluation of Et aminonicotinate sulfonylureas as antagonists of P2Y12 receptor. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
2933998090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Synthesis]
General procedure for the synthesis of 3-Boc-aminoazetidine from tert-butyl (1-diphenylmethylazetidin-3-yl)carbamate: a mixture of the feedstock (113 mg, 0.33 mmol) and 10% Pd/C catalyst (88 mg) in ethanol (3 mL) was subjected to a hydrogen atmosphere and reacted with stirring at room temperature for 2 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 3-Boc-aminoazetidine (63 mg) as a white solid. | [References]
[1] Patent: US2004/147502, 2004, A1. Location in patent: Page/Page column 23; 25
[2] Patent: WO2004/112793, 2004, A1. Location in patent: Page/Page column 147 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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