| Identification | Back Directory | [Name]
Tefinostat | [CAS]
914382-60-8 | [Synonyms]
CHR-2845
Tefinostat
Benzeneacetic acid, α-[[[4-[[8-(hydroxyamino)-1,8-dioxooctyl]amino]phenyl]methyl]amino]-, cyclopentyl ester, (αS)- | [Molecular Formula]
C28H37N3O5 | [MOL File]
914382-60-8.mol | [Molecular Weight]
495.62 |
| Chemical Properties | Back Directory | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (201.77 mM) | [form ]
Solid | [pka]
9.48±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias[1]. | [IC 50]
HDAC | [storage]
Store at -20°C | [References]
[1] Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62. DOI:10.18632/oncotarget.7692 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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