| Identification | Back Directory | [Name]
1H-1-Ethyl Candesartan Cilexetil | [CAS]
914613-35-7 | [Synonyms]
Candesartan EP Imp E
Candesartan Impurity 2
1H-1-Ethyl Candesartan Cilexetil
Candesartan Cilexetil impurity E
Candesartan Cilexetil EP IMpurity E
Candesartan Cilexetil Impurity 5(EP Impurity E)
2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Candesartan Cilexetil EP Impurity EQ: What is
Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of
Candesartan Cilexetil EP Impurity E Q: What is the storage condition of
Candesartan Cilexetil EP Impurity E Q: What are the applications of
Candesartan Cilexetil EP Impurity E | [Molecular Formula]
C35H38N6O6 | [MDL Number]
MFCD18382323 | [MOL File]
914613-35-7.mol | [Molecular Weight]
638.713 |
| Chemical Properties | Back Directory | [Melting point ]
90-93°C | [Boiling point ]
842.0±75.0 °C(Predicted) | [density ]
1.32 | [storage temp. ]
Refrigerator | [solubility ]
≤30mg/ml in DMSO;30mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
3.95±0.10(Predicted) | [Major Application]
pharmaceutical | [InChIKey]
HKUZPIFWPFYKBZ-UHFFFAOYSA-N | [SMILES]
C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C3N(CC)N=NN=3)C=C2)C2=C(C(OC(OC(OC3CCCCC3)=O)C)=O)C=CC=C2N=1 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Repr. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Candesartan Cilexetil Impurity E (PHARMEUROPA).
| [Biological Activity]
1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2]. | [References]
[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180. |
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