| Identification | Back Directory | [Name]
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile | [CAS]
915363-56-3 | [Synonyms]
Tpl2-IN-34
Cot inhibitor-2
COT INHIBITOR2; COT INHIBITOR 2
8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile
3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]aMino]- | [Molecular Formula]
C26H25Cl2FN8 | [MDL Number]
MFCD13184702 | [MOL File]
915363-56-3.mol | [Molecular Weight]
539.43 |
| Chemical Properties | Back Directory | [Boiling point ]
713.3±70.0 °C(Predicted) | [density ]
1.45 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 100 mg/mL (185.38 mM) | [form ]
Powder | [pka]
8.62±0.10(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1]. | [Definition]
ChEBI: 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile is an aminoquinoline. | [in vivo]
Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%[1]. | [storage]
Store at -20°C | [References]
[1] Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. DOI:10.1016/j.bmcl.2009.05.009 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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