| Identification | Back Directory | [Name]
4,6-Dimethyl-2-[2-(4-morpholinyl)-2-oxoethoxy]-3-pyridinecarbonitrile | [CAS]
916038-47-6 | [Synonyms]
Pim-1 kinase inhibitor 8
4,6-Dimethyl-2-[2-(4-morpholinyl)-2-oxoethoxy]-3-pyridinecarbonitrile | [Molecular Formula]
C14H17N3O3 | [MOL File]
916038-47-6.mol | [Molecular Weight]
275.3 |
| Chemical Properties | Back Directory | [Boiling point ]
520.7±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
1.36±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer[1]. | [References]
[1] Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8(49):46922-46933. DOI:10.1021/acsomega.3c06700 |
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