| Identification | Back Directory | [Name]
Homodestcardin | [CAS]
917382-84-4 | [Synonyms]
Homodestcardin
Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-(3S)-3-methyl-L-prolyl-L-isoleucyl-N-methyl-L-isoleucyl]
cyclo[N-methyl-L-alanyl-beta-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-(3S)-3-methyl-L-prolyl-L-isoleucyl-N-methyl-L-isoleucyl] | [Molecular Formula]
C32H55N5O7 | [MOL File]
917382-84-4.mol | [Molecular Weight]
621.82 |
| Chemical Properties | Back Directory | [Boiling point ]
879.1±65.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | [form ]
A solid | [pka]
13.56±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM[1]. | [IC 50]
Microbial Metabolite | [storage]
Store at -20°C | [References]
[1] Ai Hua Zhang, et al. Discovery of a new class of immunosuppressants from Trichothecium roseum co-inspired by cross-kingdom similarity in innate immunity and pharmacophore motif. Chem Asian J. 2013 Dec;8(12):3101-7. DOI:10.1002/asia.201300734 |
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