| Identification | Back Directory | [Name]
BIT225 | [CAS]
917909-71-8 | [Synonyms]
BIT225
EOS-60377
N-[5-(1-Methyl-1H-pyrazol-4-yl)-naphthalene-2-carbonyl]-guanidine
N-(Aminoiminomethyl)-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthalenecarboxamide
2-Naphthalenecarboxamide, N-(aminoiminomethyl)-5-(1-methyl-1H-pyrazol-4-yl)- | [Molecular Formula]
C16H15N5O | [MDL Number]
MFCD18633274 | [MOL File]
917909-71-8.mol | [Molecular Weight]
293.32 |
| Hazard Information | Back Directory | [Uses]
BIT-225 is an inhibitor for Vpu protein through block of Vpu ion channel, and thus inhibits the release of HIV-1, especially in monocyte-derived macrophages (EC50 is 2.25 μM), without significant cytotoxicity (TC50 is 284 μM)[1]. | [References]
[1] Khoury G, et al., Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob Agents Chemother. 2010 Feb;54(2):835-45. DOI:10.1128/AAC.01308-09 |
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