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923032-38-6

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923032-38-6 Structure

923032-38-6 Structure
IdentificationBack Directory
[Name]

BAY 869766
[CAS]

923032-38-6
[Synonyms]

RDEA119 R enantiomer
BAY 869766 R enantiomer
RefaMetinib (R enantioMer)
RefaMetinib (RDEA-119, BAY 86-9766)
Refametinib (BAY 869766) R enantiomer
RDEA119; RDEA 119; BAY 86-9766; BAY 869766; BAY869766
N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]cyclopropanesulfonamide
[Molecular Formula]

C19H20F3IN2O5S
[MDL Number]

MFCD20524892
[MOL File]

923032-38-6.mol
[Molecular Weight]

572.34
Chemical PropertiesBack Directory
[Boiling point ]

566.9±60.0 °C(Predicted)
[density ]

1.82±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

15.54±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)
GHS08
[Signal word ]

Danger
[Hazard statements ]

H361-H372
[Precautionary statements ]

P201-P202-P260-P264-P270-P281-P308+P313-P314-P405-P501
[HS Code ]

2933998090
Hazard InformationBack Directory
[Uses]

Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.
[IC 50]

MEK: 2-15 nM (EC50)
[References]

[1] Andreas Maderna, et al. N-(arylamino)-sulfonamide inhibitors of mek. WO 2007014011 A2.
Spectrum DetailBack Directory
[Spectrum Detail]

BAY 869766(923032-38-6)1HNMR
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