| Identification | Back Directory | [Name]
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- | [CAS]
928712-10-1 | [Synonyms]
HG106
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- | [Molecular Formula]
C15H13ClN4O2 | [MOL File]
928712-10-1.mol | [Molecular Weight]
316.74 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 21 mg/mL (66.30 mM);Ethanol: Insoluble | [form ]
Solid | [pka]
10.89±0.43(Predicted) | [color ]
Off-white to light yellow | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1]. | [Biological Activity]
HG106, a potent SLC7A11 inhibitor, leads to enhanced ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD). | [in vivo]
HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 26 days) inhibits tumor growth in A549 mouse transplant model[1].
HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 20 days) inhibits tumor growth in mice in a xenograft model and induces apoptosis by triggering endoplasmic membrane stress[1]. | Animal Model: | A549 mouse transplant model[1] | | Dosage: | 0, 1, 2, 4 mg/kg; daily; 26 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth and prolonged the inhibition time of tumor growth. |
| Animal Model: | LUAD patient-derived xenograft (PDX) models harboring the G12V mutation in KRAS[1] | | Dosage: | 0, 1, 2, 4 mg/kg; daily; 20 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth, increased ROS generation and TUNEL signal in patient-derived xenografts validated that HG106 triggered endoplasmic membrane stress-induced apoptosis in vivo. |
| [References]
[1] Hu K, et al. J Clin Invest. 2020 Apr 1;130(4):1752-1766. |
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
NewCan Biotech Limited
|
| Tel: |
+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
|