| Identification | Back Directory | [Name]
CDDO-EA | [CAS]
932730-51-3 | [Synonyms]
TP319
TP 319
RTA405
RTA-405
RTA 405
CDDO-EA
TP-319)
CS-1305
CDDO ethyl amide
Bardoxolone ethyl amide
CDDO EA, RTA 405, tP 319
CDDO-EA
(CDDO ethyl amide
Oleana-1,9(11)-dien-28-amide, 2-cyano-N-ethyl-3,12-dioxo-
CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319 | [Molecular Formula]
C33H46N2O3 | [MDL Number]
MFCD11983136 | [MOL File]
932730-51-3.mol | [Molecular Weight]
518.73 |
| Chemical Properties | Back Directory | [Boiling point ]
670.7±55.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 34 mg/mL (65.54 mM) | [form ]
Powder | [pka]
16.21±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. | [Biological Activity]
CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator. | [in vitro]
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. | [in vivo]
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%). | [target]
| [References]
[1] Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96. DOI:10.1016/j.freeradbiomed.2011.03.027
[2] Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9. DOI:10.1158/0008-5472.CAN-06-4534 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
|