| Identification | More | [Name]
1H-BENZOIMIDAZOL-5-YLAMINE | [CAS]
934-22-5 | [Synonyms]
1H-1,3-BENZIMIDAZOL-5-AMINE
1H-BENZIMIDAZOL-5-YLAMINE
1H-BENZO[D]IMIDAZOL-6-AMINE
1H-BENZOIMIDAZOL-5-YLAMINE
3H-BENZOIMIDAZOL-5-YLAMINE
5-AMINOBENZIMIDAZOLE
TIMTEC-BB SBB010145
1h-benzimidazol-5-amine
5-amino-benzimidazol
6-amino-benzimidazol
6-aminobenzimidazole
benzimidazol-5-ylamine
1H-Benzimidazol-6-amine, 3H-Benzoimidazol-5-ylamine
6-Amino-1H-benzimidazole
1H-Benzimidazol-5-amine(9CI)
1H-Benzimidazole-6-amine
5-Amino-1H-benzimidazole
6-Amino-1H-benzoimidazole | [EINECS(EC#)]
213-279-0 | [Molecular Formula]
C7H7N3 | [MDL Number]
MFCD00465258 | [Molecular Weight]
133.15 | [MOL File]
934-22-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
163-168 °C | [Boiling point ]
222°C/3.5mmHg(lit.) | [density ]
1.367 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
slightly sol. in Methanol | [form ]
powder to crystal | [pka]
14.47±0.30(Predicted) | [color ]
Light yellow to Brown | [λmax]
300nm(EtOH)(lit.) | [InChI]
InChI=1S/C7H7N3/c8-5-1-2-6-7(3-5)10-4-9-6/h1-4H,8H2,(H,9,10) | [InChIKey]
WFRXSXUDWCVSPI-UHFFFAOYSA-N | [SMILES]
C1NC2=CC(N)=CC=C2N=1 | [CAS DataBase Reference]
934-22-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [RTECS ]
DD5785000 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Uses]
5-Aminobenzimidazole is a useful research chemical. It inhibits gastric acid secretion in Shay-rats. Urinary metabolite of cambendazole. | [Synthesis]
The general procedure for the synthesis of 5-amino benzimidazole from 5-nitrobenzimidazole was as follows: 5-nitrobenzimidazole (10.0 g, 61.3 mmol) was dissolved in methanol (250 mL) and 10% Pd/C catalyst (0.40 g) was added. The hydrogenation reaction was carried out under atmospheric pressure hydrogen atmosphere for 20 hours. Upon completion of the reaction, the catalyst was removed by Celite filtration. The filtrate was concentrated under reduced pressure to give pure 5-aminobenzimidazole (yield not provided). | [References]
[1] Patent: WO2005/66156, 2005, A1. Location in patent: Page/Page column 33
[2] Patent: EP1437344, 2004, A1. Location in patent: Page 37
[3] Patent: WO2014/162039, 2014, A1. Location in patent: Page/Page column 40
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 2362 - 2370
[5] Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 45,48,51 |
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