| Identification | Back Directory | [Name]
4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, methyl ester, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)- | [CAS]
934005-36-4 | [Synonyms]
4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, methyl ester, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)- | [Molecular Formula]
C23H34O4 | [MOL File]
934005-36-4.mol | [Molecular Weight]
374.51 |
| Chemical Properties | Back Directory | [Boiling point ]
516.5±50.0 °C(Predicted) | [density ]
1.014±0.06 g/cm3(Predicted) | [solubility ]
Ethanol: 1 mg/ml | [pka]
13.75±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Protectin D1 methyl ester is an esterified form of the specialized pro-resolving mediator protectin D1 . It is an intermediate in the synthesis of protectin D1.1 Protectin D1 methyl ester (333 μg/kg) reduces infarct area and volume and increases blood vessel density in the tissue surrounding the infarct in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).2 | [Uses]
Neuroprotectin D1 methyl ester is an esterified form of Protectin D1 (HY-130413). Neuroprotectin D1 methyl ester is an intermediate in the synthesis of Protectin D1. | [References]
1. Rodriguez, A.R., and Spur, B.W. Total synthesis of the potent anti-inflammatory lipid mediator Protectin D1 Tetrahedron Lett. 55(43),6011-6015(2014).
2. Bazan, N.G., Eady, T.N., Khoutorova, L., et al. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke Exp. Neurol. 236(1),122-130(2012). |
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