| Identification | Back Directory | [Name]
PF-03654746 (free base) | [CAS]
935840-31-6 | [Synonyms]
PF-03654746
PF-03654746 (free base)
SXMBKHYDZOCBMT-PPUGGXLSSA-N | [Molecular Formula]
C18H24F2N2O | [MOL File]
935840-31-6.mol | [Molecular Weight]
322.39 |
| Chemical Properties | Back Directory | [Boiling point ]
460.5±45.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
15.89±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration.
PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis[1].
PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2]. | [storage]
Store at -20°C | [References]
[1] Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. DOI:10.1016/j.jaci.2011.11.026
[2] Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46. DOI:10.1124/jpet.110.166876 |
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