936500-94-6

Directory

936500-94-6 Structure

Identification	Back Directory
[Name] 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide
[CAS] 936500-94-6
[Synonyms] elinogrel PRT 060128 P2Y Receptor,inhibit,PRT 060128,Elinogrel,Inhibitor,PRT-060128 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(MethylaMino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]aMino]carb 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide 2-Thiophenesulfonamide, 5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-
[Molecular Formula] C20H15ClFN5O5S2
[MDL Number] MFCD16619373
[MOL File] 936500-94-6.mol
[Molecular Weight] 523.95

Hazard Information	Back Directory
[Description] Elinogrel is a reversible antagonist of the platelet purinergic P2Y₁₂ receptor (K_i = 23 nM) that inhibits platelet aggregation in a human platelet-rich plasma (hPRP) assay (IC₅₀ = 2.81 nM). It inhibits thrombosis in a mouse model of vascular injury induced by iron (III) chloride (FeCl₃) when administered at a dose of 60 mg/kg.
[Uses] Elinogrel is a direct acting reversible P2Y12 inhibitor, which shows an antiplatelet effect and platelet reactivity associated with cytochrome P 450 2C19 and 3A5 gene polymorphisms.
[IC 50] P2Y12 Receptor
[storage] Store at -20°C
[References] [1] GERNOT ZECH. Identification of High-Affinity P2Y12 Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone[J]. Journal of Medicinal Chemistry, 2012, 55 20: 8615-8629. DOI: 10.1021/jm300771j [2] HELENA HABERSTOCK-DEBIC. A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation: inhibition by elinogrel, a direct-acting, reversible P2Y12 antagonist.[J]. ACS Applied Electronic Materials, 2011: 54-61. DOI: 10.1124/jpet.111.184143

Spectrum Detail	Back Directory
[Spectrum Detail] 5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide(936500-94-6)¹HNMR

936500-94-6 suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Website:	www.atkchemical.com

Company Name:	CONIER CHEM AND PHARMA LIMITED
Tel:	+8618523575427 , +8618523575427
Website:	http://www.conier.com/

Company Name:	Shanghai EFE Biological Technology Co., Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

Company Name:	Shanghai YuanYe Biotechnology Co., Ltd.
Tel:	021-61312847; 18021002903
Website:	http://www.shyuanye.com

Company Name:	Shanghai Chaolan Chemical Technology Center
Tel:	021-QQ：65489617 15618227136
Website:	www.atkchemical.com/

Company Name:	cjbscvictory
Tel:	13348960310
Website:	https://www.weikeqi-biotech.com/

Company Name:	Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel:	400-6206333 13167063860
Website:	www.aladdin-e.com/

Tags:936500-94-6 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login