| Identification | Back Directory | [Name]
neo-gambogic acid | [CAS]
93772-31-7 | [Synonyms]
neo-gambogic acid
4-[3a,4,5,7,10,11-Hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-2-butenoic acid
2-Butenoic acid,4-[3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-
2-Butenoic acid, 4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-, (2Z)- | [Molecular Formula]
C38H46O9 | [MDL Number]
MFCD12031633 | [MOL File]
93772-31-7.mol | [Molecular Weight]
646.772 |
| Chemical Properties | Back Directory | [Boiling point ]
801.0±65.0 °C(Predicted) | [density ]
1.32 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
cryst. | [pka]
4.58±0.36(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Neogambogic Acid is an active ingredient or one of the main components of gamboge that induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA). | [Synthesis]
A literature review on optimizing the extraction and isolation of neo-gambogic acid from Garcinia hanburyi:
1. Optimization of extraction (orthogonal tests): effects of solvent, time, cycles, and solid-to-liquid ratio.
2. Purification: Adsorption/pu | [in vivo]
Neogambogic acid arrests A549-induced tumor growth in nude mice[1]. | [storage]
Store at -20°C |
|
|