| Chemical Properties | Back Directory | [solubility ]
DMSO:44.75(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:44.75(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin. | [Uses]
K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research[1]. | [IC 50]
α5β1 | [storage]
Store at -20°C | [References]
[1] Martinkova E, et al. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010 Sep 1;127(5):1240-8. DOI:10.1002/ijc.25187 |
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