| Identification | Back Directory | [Name]
OrfaMide B | [CAS]
939960-35-7 | [Synonyms]
OrfaMide B
L-Valine, N-(3-hydroxy-1-oxotetradecyl)-L-leucyl-D-α-glutamyl-D-allothreonyl-D-valyl-L-leucyl-D-seryl-L-leucyl-L-leucyl-D-seryl-, (10→3)-lactone | [Molecular Formula]
C63H112N10O17 | [MDL Number]
MFCD33021589 | [MOL File]
939960-35-7.mol | [Molecular Weight]
1281.62 |
| Hazard Information | Back Directory | [Description]
Orfamide B is a cyclic lipopeptide originally isolated from P. fluorescens. It is the main orfamide produced by Pseudomonas sp. CMR12a. Orfamide B inhibits mycelial growth and increases hyphal branching in the fungi R. solani AG2-1 at concentrations of 10 and 100 μM and in R. solani AG 4-HGI at a concentration of 100 μM. | [Uses]
Orfamide B is a component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced by orphan gene clusters containing non-ribosomal peptide synthetases. Orfamide B has not been further investigated, although its activity is thought to parallel that of orfamide A and other cyclic lipopeptides produced by Pseudomonas. | [Uses]
Orfamide B is a cyclic lipopeptide produced by Pseudomonas fluorescens. | [References]
[1] HARALD GROSS. The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.[J]. Chemistry & biology, 2007, 14 1: 53-63. DOI: 10.1016/j.chembiol.2006.11.007
[2] FEYISARA EYIWUMI OLORUNLEKE. Interplay between orfamides, sessilins and phenazines in the control of Rhizoctonia diseases by Pseudomonas sp. CMR12a[J]. Environmental Microbiology Reports, 2015, 7 5: 774-781. DOI: 10.1111/1758-2229.12310 |
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