| Identification | Back Directory | [Name]
1,2,4-Triazolo[3,4-b]benzothiazol-3-amine, 5,8-dimethoxy- | [CAS]
943119-42-4 | [Synonyms]
OUL232
1,2,4-Triazolo[3,4-b]benzothiazol-3-amine, 5,8-dimethoxy- | [Molecular Formula]
C10H10N4O2S | [MOL File]
943119-42-4.mol | [Molecular Weight]
250.28 |
| Hazard Information | Back Directory | [Uses]
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1]. | [IC 50]
PARP7: 83 nM (IC50); PARP10: 7.8 nM (IC50); PARP14: 300 nM (IC50); PARP15: 56 nM (IC50); PARP1: 15 μM (IC50); PARP2: 10 μM (IC50); PARP3: 50 μM (IC50); PARP4: 11 μM (IC50); TNKS1: 5.4 μM (IC50); TNKS2: 10 μM (IC50); PARP11: 240 nM (IC50); PARP12: 160 nM (IC50); PARP16: 3.4 μM (IC50) | [References]
[1] Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4. DOI:10.1021/acs.jmedchem.2c01460 |
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