| Identification | Back Directory | [Name]
2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamidebutanedioicacid | [CAS]
943650-25-7 | [Synonyms]
CS-2220
ABT 472
AKOS016845980
DTXSID70670431
ABT 472,ABT472
A-620223 (HCl salt)
A-620223 (Succinate)
2-(1-Propylpiperidin-4-yl)-1H-benzo[d]iMidazole-7-carboxaMide succinate
2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamidebutanedioicacid
Butanedioic acid compd. with 2-(1-propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide | [Molecular Formula]
C20H28N4O5 | [MDL Number]
MFCD16660942 | [MOL File]
943650-25-7.mol | [Molecular Weight]
404.46 |
| Hazard Information | Back Directory | [Uses]
A-620223 succinate (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 succinate (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1]. | [References]
[1] Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. DOI:10.1016/j.bmc.2008.05.044 |
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| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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