| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- | [CAS]
945396-55-4 | [Synonyms]
AZ12672857
2,4-Pyrimidinediamine, N2-(3,5-di-4-morpholinylphenyl)-N4-1H-indazol-4-yl-N4-methyl- | [Molecular Formula]
C26H30N8O2 | [MDL Number]
MFCD32874133 | [MOL File]
945396-55-4.mol | [Molecular Weight]
486.57 |
| Hazard Information | Back Directory | [Uses]
AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM)[1]. | [IC 50]
Src | [storage]
Store at -20°C | [References]
[1] Bardelle C, et al. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett. 2010;20(21):6242-6245. DOI:10.1016/j.bmcl.2010.08.100 |
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MedChemExpress
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